Full Spectrum Infrasonic Stethoscope for Screening Heart, Carotid Artery, and Lung Related Diseases

Blood circulation carries vibrations due to heart beat to every part of the body. These vibrations result in minute displacements that are measured by the detector. Defective closures lead to backflow of blood into chambers leading to heart beat slowdown. Displacement strength is indicative of vibration strength which in turn is indicative of heart beat. Weak vibrations at toes, for example, indicate poor circulation of blood as in the case of diabetic issues. Similarly, in other parts of the body, this unit would help in early detection of diabetes and other diseases by noninvasively monitoring blood circulation at various regions of a human body. As such, this unit would detect precursors for diseases. For astronauts and other operatives, this device could remotely provide the status of their cardiac cycles during physical activities. The device consists of a laser transmitter, photo-EMF detector and interferometric architecture which provides motion detection. Motion detection aids in measuring displacements. There is also a "speckle tolerant" property allowing data to be collected from conformal and rough target surfaces such as garments. Surface preparation is not needed such as in ECG and other cases. The novel Photo-EMF detector will be able to measure displacements of less than 1 pm.

Large aircraft can generate air vortices in their wake, turbulence that can prove hazardous to aircraft that follow too closely. Because wake vortices are invisible, all takeoffs at busy airports are spaced several minutes apart. This separation gives the vortices time to dissipate, even though they only occur 10% of the time, with resulting loss of operational efficiency. Similarly, clear air turbulence is invisible and can also be hazardous to aircraft. By detecting such disturbances through their infrasound emissions, precautions can be taken to avoid them. Other phenomena can be detected through infrasound, including tornadoes, helicopters on the other side of mountains, underground nuclear explosions and digging tunnels. Through the unique properties of infrasound, many of these can be detected from hundreds of miles away. NASA's infrasound sensor is a highly refined microphone that is capable of detecting acoustic waves from 20 Hz down to dc, the infrasound range. The design is robust and compact, eliminating the bulk and weight found in other technologies. Where most alternative methods are restricted to certain weather conditions and locations, the NASA sensor filters noise from wind and other sources, allowing its use under any weather or geographic conditions.

The technology utilizes four cutting-edge sensor technologies to enable minimally- or non-invasive analysis of various biological samples, including saliva, breath, and blood. The combination of technologies and sample pathways have unique advantages that collectively provides a powerful analytical capability. The four key technology components include the following: (1) the carbon nanotube (CNT) array designed for the detection of volatile molecules in exhaled breath; (2) a breath condenser surface to isolate nonvolatile breath compounds in exhaled breath; (3) the miniaturized differential mobility spectrometer (DMS) -like device for the detection of volatile and non-volatile molecules in condensed breath and saliva; and (4) the miniaturized circular disk (CD)-based centrifugal microfluidics device that can detect analytes in any liquid sample as well as perform blood cell counts. As an integrated system, the device has two ports for sample entry a mouthpiece for sampling of breath and a port for CD insertion. The breath analysis pathway consists of a CNT array followed by a condenser surface separating liquid and gas phase breath. The exhaled breath condensate is then analyzed via a DMS-like device and the separated gas breath can be analyzed by both CNT sensor array again and by DMS detectors.

Langley has developed various technologies to enable the portable detection system, including: - 3-inch electret condenser microphone - unprecedented sensitivity of -45 dB/Hz - compact nonporous windscreen - suitable for replacing spatially demanding soaker hoses in current use - infrasonic calibrator for field use - piston phone with a test signal of 110 dB at 14Hz. - laboratory calibration apparatus - to very low frequencies - vacuum isolation vessel - sufficiently anechoic to permit measurement of background noise in microphones at frequencies down to a few Hz - mobile source for reference - a Helmholtz resonator that provides pure tone at 19 Hz The NASA system uses a three-element array in the field to locate sources of infrasound and their direction. This information has been correlated with PIREPs available in real time via the Internet, with 10 examples of good correlation.

Many diseases are accompanied by characteristic odors. Their recognition can provide diagnostic clues, guide the laboratory evaluation, and affect the choice of immediate therapy. The study of the chemical composition of human breath using gas chromatography mass spectrometry (GC/MS) has shown a correlation between the volatile compounds and the occurrence of certain illnesses. The presence of those specific compounds can provide an indication of physiological malfunction and support the diagnosis of diseases. This condition requires an analytical tool with very high sensitivity for its measurement. A number of volatile compounds, so called biomarkers, are found in breath samples, normally at low parts per billion (ppb) levels. For example, the acetone in the exhaled breath from human with other biomarkers can indicate Type I diabetes. Usually, the concentration of the volatile compounds in human breath is very low and the background relative humidity is high, almost 100%. NASAs invention utilizes an array of chemical sensors combined with humidity, temperature, and pressure for real-time breath measurement to correlate the chemical information in the breath with the state and functioning of different human organs. This tool provides a non-invasive method for fast and accurate diagnosis at the medical point of care or at home. The sensor chip includes multisensors for a comprehensive measurement of chemical composition, temperature, humidity, and pressure/flow rate. The sensor data collected from this chip can be wired or wirelessly transmitted to a computer terminal at the doctors desk or hospital monitoring center. The sensor chip can be connected directly or via Universal serial bus (USB) to a cell phone for data transmission over a long distance and receive an instruction from a doctors office for an immediate therapy.