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In the development of this technology for the ISS, engineers had to pay careful attention to electrical draw efficiency, ease-of-use, mass reduction, production cost, and safety, as conducting scientific research under spacecraft stressors is an important requirement. To create a controlled environment within the science enclosure, engineers designed a ventilation system incorporating an external fan/blower that pulls air across a HEPA filter and diffuses it in a manner that creates an even laminar flow within the enclosure before exiting through the exhaust filter. The glove seal forms an airtight and liquid impervious seal. This novel design also allows the user flexibility to choose their own task-specific glove material, facilitates easy tool-free assembly and quick glove changes, and may be transferable to other types of enclosures. Another key feature is that a through-port can be quickly fitted to an empty glove port. Due to the science enclosure system intended application aboard the ISS, its electrical draw does not exceed 24V, thereby making it feasible to power it from a battery for terrestrial field use or other applications where accessing power is a challenge. The combination of its performance, portability, BSL 2 capability, and inexpensive production costs could position the science enclosure system and accompanying innovations to be valuable in the fields of education, research, clean rooms, hospitals, and disaster relief efforts.

In space there are a limited number of care providers, and those providers are not always clinicians with extensive medical training. Space travel also has limited room to provide care and limited consumables. The Human-Powered Ventilator is compact, portable, and easy to assemble. It is designed so that users can implement hand and arm movements to pump the bellows between two hinged, clamshell-like panels back and forth to provide positive pressure ventilation to the patient. A light spring is incorporated into the design to assist in expanding the bellows, drawing air out of the patient’s lungs, and reducing the physical load on the operator without compromising the tactile feel necessary for proper usage. The airflow can be supplemented with prescribed medical vapors, oxygen, etc. via standard industry fittings. The Human-Powered Ventilator is TRL 6 (system/subsystem prototype has been demonstrated in a relevant environment) and it is now available for your company to license. Please note that NASA does not manufacture products itself for commercial sale.

Most magnetic therapy research and resulting devices have centered around pulsed unidirectional bioelectric systems. The technology available here for licensing utilizes a square-wave time-varying electrical current, which generates an electromagnetic field, via a wound coil incorporated into a sleeve and encircles the affected appendage. An external and commercially available time-varying compact electrical generator connects to the wound coil within the sleeve and is powered by a 9-volt battery. Prior industry attempts to use electromagnetic therapy on mammalian tissue have historically applied higher than necessary levels of electromagnetism, typically at 50 gauss or more. Researchers found that by inducing a Fourier-curve, time-varying electromagnetic wave at levels within 0.05 0.5 gauss for a pre-determined time-period, was optimum to achieve successful mammalian tissue regeneration. It is theorized that magnetic fields can alter the flow of positively charged calcium ions that interact with the muscles around small blood vessels causing them to relax. This effect in turn, causes constricted blood vessels to dilate, and dilated blood vessels to constrict. Depending upon the type of injury, enhanced tissue repair may occur through the suppression of inflammation, or the increase in blood flow.

The technology is an all-printed Physically Unclonable Function (PUF) electronic device based on a nanomaterial (such as single-walled carbon nanotube) network. The network may be a mixture of semiconducting and metallic nanotubes randomly tangled with each other through the printing process. The all-printed PUF electronic device comprises a nanomaterial ink that is inkjet deposited, dried, and randomly tangled on a substrate, creating a network. A plurality of electrode pairs is attached to the substrate around the substrate perimeter. Each nanotube in the network can be a conduction path between electrode pairs, with the resistance values varying among individual pairs and between networks due to inherent inter-device and intra-device variability. The unique resistance distribution pattern for each network may be visualized using a contour map based on the electrode information, providing a PUF key that is a 2D pattern of analog values. The PUF security keys remain stable and maintain robustness against security attacks. Although local resistance change may occur inside the network (e.g., due to environmental impact), such change has little effect on the overall pattern. In addition, when a network-wide resistance change occurs, all resistances are affected together, so that the unique pattern is maintained.

The handheld digital microscope features a 3D-printed chassis to house its hardware, firmware, and rechargeable Li-ion battery with built-in power management. It incorporates an internal stainless-steel cage system to enclose and provide mechanical rigidity for the optics and imaging sensor. To reduce the microscope’s size, yet retain high spatial resolution, engineers devised an optical light path that uniquely folds back on itself using high reflectivity mirrors, thus significantly reducing internal volume. Imaging control and acquisition is performed using a secure web-based graphical user interface accessible via any wireless enabled device. The microscope serves as its own wireless access point thus obviating the need for a pre-existing network. This web interface enables multiple simultaneous connections and facilitates data sharing with clinicians, scientists, or other personnel as needed. Acquired images can be stored locally on the microscope server or on a removable SD card. Data can be securely downloaded to other devices using a range of industry standard protocols. Although the handheld digital microscope was originally developed for in-flight medical diagnosis in microgravity applications, prototypes were thoroughly ground-tested in a variety of environments to verify the accurate resolve of microbial samples for identification and compo-sitional analysis for terrestrial field use. Owing to its portability, other applications demanding rapid results may include research, education, veterinarian, military, contagion disaster response, telemedicine, and point-of-care medicine.

To stain a specimen slide, one or more liquid reagents are injected via the dispenser into the slide staining device via a syringe port. The volume of a given reagent is determined by adjustable settings on the dispenser, so that when connected to the staining device, initiates a thin film over the slide. The dispensing device uses only a fraction of the reagents typically used in non-sealed environments. Medical grade polyvinyl alcohol sponges have been incorporated into the dispenser to provide additional fluid containment and retention during the staining procedure. Furthermore, the dispenser can recall excess reagent, minimizing reagent use until refill. The slide staining device is composed of an upper and lower section held together and aligned by use of Nd magnets. With the device open, a specimen slide is positioned upon a silicone gasket that sits within a recess in the lower section. When the device is closed, the silicone gasket in the upper section applies a seal to the slide forming a cavity that allows the slide to be exposed to reagents injected from the connected dispenser creating a stain through the use of capillary forces. Although originally designed for use in microgravity, the slide staining system also works in gravity environments. Numerous applications may exist for this technology, particularly in hematology and cellular biology. Other applications could be considered for academic research, veterinary field use, military, disaster stricken and remote environments or where fine control of fluid delivery, removal, and management is desired. The slide staining system is at technology readiness level (TRL) 8 (actual system completed and "flight qualified" through test and demonstration), and are now available to license. Please note that NASA does not manufacture products itself for commercial sale.